The impact of e-cigarettes on genetic material DNA

Many studies have shown that e-cigarettes can cause damage to DNA [1-2].

In 2018, Lee et al. [3] conducted a mouse experiment showing that inhaling e-cigarette smoke can damage DNA in the lungs, heart, and bladder, and can also induce the same effect on DNA in human bronchial epithelial and urothelial cells cultured in vitro.

The study covered the results of animal and human experiments and speculated that the use of e-cigarettes may lead to human lung cancer, bladder cancer, and heart disease. Chen et al. [4] conducted a mouse experiment that also proved that exposure to e-cigarettes not only has an adverse effect on maternal lung health, but also damages DNA in the lungs of offspring.

There is evidence that nicotine use by pregnant women may damage the brain development of the fetus [5].

Reference:

［1］YU V，RAHIMY M，KORRAPATI A. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines［J］. Oral Oncol，2016，52 ：58-65.

［2］GANAPATHY V，MANYANGA J，BRAME L，et al. Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damage［J］. PLoS One，2017，12（5）：e0177780.

［3］LEE H W，PARK S H，WENG M W，et al. E-cigarette smoke damages DNA and reduces repair activity in mouse lung heart，and bladder as well as in human lung and bladder cells［J］. Proc Natl Acad Sci USA，2018，115（7）：E1560- E1569.

［4］CHEN H，LI G，CHAN Y L，et al. Maternal e-cigarette exposure in mice alters DNA methylation and lung cytokine expression in offspring［J］. Am J Respir Cell Mol Biol，2017，58（3）：366-377.

［5］DWYER J B，BROIDE R S，LESLIE F M. Nicotine and brain development［J］. Birth Defects Res C Embryo Today，2008，84（1）：30-44.