NICOTINE PHARMACOLOGY

NICOTINE PHARMACOLOGY
  • Nov 13, 2024
  • Product/ Academy

Nicotine, an alkaloid extracted from tobacco plants.

Nicotine use results in rewarding effects on mood, cognition, stress and anxiety, facilitated by release of various neurotransmitters (ie, dopamine, norepinephrine, acetylcholine, glutamate, serotonin, GABA, endorphins).

Nicotine reaches the brain most quickly via the lungs and arterial blood.

rise in the blood 4–6 hours
dayplateau throughout the day
nightdecline overnight
half-life2 hours
cross the BBB8 secs

Constant nicotine exposure results in high risk of developing dependence symptoms, including tolerance and withdrawal.

Nicotine is a chiral molecule with two stereoisomers.

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Little is known about the pharmacological and metabolic effects of R-nicotine in humans.
R-nicotine is a significantly less potent (~10-fold) agonist of nicotine receptors than S-nicotine.

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