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(1.Shanghai Municipal Center for Health Promotion, Shanghai 200040, China; 2.Shanghai Association of Tobacco Control, Shanghai 200040, China; 3.Shanghai Municipal Health Commission, Shanghai 200125, China)

Department of Pulmonary and Critical Care Medicine, Peking University International Hospital, Beijing 102206, China

Nebulizing inhalation combined with non-invasive ventilation therapy in COPD patients with respiratory failure and nursing．

Aerosol administration during noninvasive ventilation (NIV) is a common clinical drug administration method, but the drug administration efficiency of different drug delivery devices is different.

Nasal aerosol inhalation is increasingly used in intensive care units (ICUs). In pediatric wards in the United States, 75% of patients receive nasal aerosol inhalation therapy, while the rest use traditional nebulization methods.

Nebulizer inhalation can humidify the respiratory tract, reduce inflammation, relieve cough and eliminate phlegm. It can also promote the absorption and excretion of inflammatory secretions. It has few side effects, shortens the course of the disease and has better therapeutic effects.

The study about the factors that affect the effect of nebulized inhalation by HFNC, among which VMN is more suitable for atomization inhalation therapy combined with HFNC.

Study on atomizing suction and atomizing particle size settling position，according to professional research data, the particle size of drug administration atomization into the lung is preferably 2-5 μm.