NICOTINE PHARMACOLOGY

Nicotine, an alkaloid extracted from tobacco plants. Nicotine use results in rewarding effects on mood, cognition, stress and anxiety, facilitated by release of various neurotransmitters (ie, dopamine, norepinephrine, acetylcholine, glutamate, serotonin, GABA, endorphins). Nicotine reaches the brain most quickly via the lungs and arterial blood. rise in the blood  4–6 hours day plateau throughout the day night decline overnight half-life 2 hours cross the BBB 8 secs […]